JCO PO is a peer-reviewed, online-only, article-based journal publishing original research, reports, opinions, and reviews that advance the science and practice of precision oncology and define genomics- and other biomarker-driven clinical care of patients with cancer. Innovative and timely scientific and educational content provide a deeper understanding of actionable cancer genomics, personalized translational and clinical oncology research, and recent treatment advances based on tumor molecular profiling. The scope of publications includes all types of clinical research (basket trials, exceptional response results, informatics, computational approaches, mechanism and evidence-based case reports and small series of educational value), and extensive expert driven commentary, editorials and reviews considering the challenges and value of targeted therapies based on genomic analyses. JCO PO is published by the American Society of Clinical Oncology (ASCO).